Defining the role of the KRAS-variant in cell transformation. Using unique isogenic cell line models, we have been working to define the fundamental changes caused by the KRAS-variant, to understand its powerful impact on human cancer risk and treatment response.
Applying other microRNA disrupting mutations to cancer therapy. We have applied panels of our discovered mutations and applied them to specific cancer treatment strategies, to identify powerful biomarkers to further personalize cancer treatment. cancer treatment strategies, to identify powerful biomarkers to further personalize cancer treatment.
Defining functional microRNA biologic responses to stress. Based on our novel findings that the microRNA, miR-34, undergoes activation through phosphorylation in response to radiation, we have been working to dissect the mechanisms behind this extremely exciting insight into differential microRNA regulation.